Dictionary

U

Ultra-Orphan DrugTermUltra-Orphan Medicine, Very-Rare-Disease Drug

A treatment for an extremely rare disease, an even smaller subset of orphan diseases, posing particularly acute evidentiary challenges.

Ultra-Rare DiseaseTermVery Rare Disease, Ultra-Rare Condition

A disease affecting an extremely small number of people, an even smaller subset of rare diseases, posing acute evidentiary challenges.

Umbrella ReviewTermReview of Reviews, Overview of Reviews

A systematic review summarising evidence from multiple existing systematic reviews addressing related questions, rather than synthesising individual primary studies.

Umbrella TrialTermUmbrella Study, Multi-Arm Biomarker Trial

A trial design evaluating multiple targeted treatments within a single disease type, assigning patients to arms based on specific genetic or molecular markers.

UnbiasednessConceptUnbiased Estimation, Zero-Bias Property

Unbiasedness is the property of an estimator, such as a trial's mean cost, whose average over repeated samples equals the true value it estimates.

Unbundled PaymentTermComponent Payment, Itemised Payment

A payment approach reimbursing separately for each individual component service, rather than combining them into a single comprehensive payment.

UnbundlingTermFragmented Billing, Component Billing

A billing practice separately billing individual components of a service that should properly be billed together under one comprehensive code.

UncertaintyConceptImperfect Knowledge, Incomplete Information

Uncertainty in health economics is imperfect knowledge of a model's true inputs, structure or methods, so the option chosen as best may prove to be wrong.

Uncertainty AssessmentTermUncertainty Evaluation, Uncertainty Appraisal

A systematic evaluation of how confident decision-makers should be in a model's results, given parameter, structural, and methodological uncertainty.

Uncertainty QuantificationConceptUQ, Numerical Uncertainty Analysis

Uncertainty quantification (UQ) measures how uncertainty in a health economic model's inputs and structure carries into its costs, QALYs and decision.

Uncompensated CareTermUnreimbursed Care

Healthcare services provided for which no payment is received, covering both free charity care and unpaid bad debt.

Uncontrollable CostTermNon-Controllable Cost, Non-Discretionary Cost

A cost that a specific manager or department cannot influence through their own decisions, often set at a higher organisational level.

Undercoverage RateTermCoverage Shortfall Rate, Non-Coverage Rate

The proportion of a programme's intended eligible population that does not actually receive its benefits, whether from awareness, administrative, or targeting failures.

UnderfittingTermModel Underfit, High-Bias Model

A situation in which a model is too simple to capture the true underlying relationship, performing poorly on both training and new data.

UnderinsuranceTermUnderinsured Status, Inadequate Coverage

A situation where an individual has insurance that is insufficiently comprehensive to provide adequate financial protection, often from high deductibles or limited benefits.

UnderuseTermUnderutilisation, Missed Effective Care

The failure to provide a service that would have produced a favourable outcome, representing a missed opportunity for beneficial care.

UnderwritingTermRisk Assessment Pricing, Premium Rating

The process by which an insurer evaluates the risk of a potential policyholder and determines whether to offer coverage and at what price.

Undue InducementTermExcessive Inducement, Improper Incentive

An offer so substantial it could overwhelm a prospective participant's rational judgement about risk, compromising the voluntariness of their consent.

Uniform DistributionConceptRectangular Distribution, Flat Prior

The uniform distribution gives equal density to every value between two bounds and is used in health economic models for inputs known only by their range.

Unimodal HazardConceptSingle-Peak Hazard, Hump-Shaped Hazard

A unimodal hazard is an event rate that rises to a single peak and then falls, as log-logistic and log-normal survival models allow in HTA.

UniquenessTermUnique Variance, Specific Variance

In factor analysis, the proportion of an observed variable's total variance not explained by the underlying common factors, including error.

Unit CostTermResource Unit Price, Input Price

The cost of producing or delivering a single unit of a good or service, such as the cost per hospital bed-day.

Unit Cost EstimationTermUnit Costing, Component Cost Derivation

The process of determining the cost of delivering a single, standardised unit of a healthcare service, such as an inpatient bed-day.

Unit of AllocationConceptUnit of Randomisation, Unit of Randomization

The unit of allocation is the patient, practice, hospital or other entity a trial randomises to each arm; the analysis must allow for that level.

Unit TestingTermComponent Testing, Module Testing

A verification technique testing individual, isolated model components, such as a single formula, to confirm each works correctly on its own.

Unit Value TransferTermUnit Value Benefit Transfer, Single-Value Transfer

The simplest form of benefit transfer, applying a single mean value from an original study directly to a new context without adjustment.

Unitary SystemTermCentralised Health System, Unitary Health System

A health system structure in which a single, centralised government authority holds primary responsibility for policy, financing, and often delivery.

Universal Health CoverageConceptUHC, Health Coverage for All

Universal health coverage (UHC) means everyone can use the quality health services they need, when and where they need them, without financial hardship.

Universal Health Coverage IndexConceptUHC Index, UHC Service Coverage Index

Universal Health Coverage Index (UHC service coverage index) is WHO's 0 to 100 score for SDG 3.8.1, built from 14 tracer measures of service coverage.

Unmarketed GoodConceptNon-Market Good

An unmarketed good is an economic good, such as health or clean air, that is not traded in markets, so no market price shows its value in appraisal.

Unmeasured ConfoundingTermHidden Confounding, Unobserved Confounding

A situation where a true confounder exists but was not recorded, preventing statistical adjustment for its distorting effect on an association.

Unmet Medical NeedTermHigh Unmet Need, Therapeutic Gap

A health condition for which no satisfactory approved treatment currently exists, or existing treatments do not adequately address important aspects.

Unmet NeedConceptUnmet Health Need, Care Shortfall, Foregone Care, Cost-Related Nonreceipt, Skipped Care

Unmet need is health care a person needed but did not receive; in drug regulation, unmet medical need is a condition without adequate treatment.

Unmet Need CriterionTermUnmet Need Modifier, High-Unmet-Need Criterion

A standard giving additional favourable consideration to a technology addressing a condition for which no adequate existing treatment is available.

Unrelated Future CostTermUnrelated Medical Cost, Future Unrelated Cost, Unrelated Cost

Future healthcare costs in added years of life gained from treatment that arise from entirely unrelated health conditions, a particularly unresolved methodological issue.

Unrestricted ListingTermOpen Listing, Unrestricted Reimbursement, General Listing, Open Formulary Listing, Standard Listing

The inclusion of a treatment on a formulary without limitations on patient eligibility or prior authorisation, following a positive value finding.

Unstructured CorrelationConceptUnstructured Covariance, Unstructured Working Correlation

Unstructured correlation lets each trial visit have its own variance and each pair of visits its own correlation in models of repeated utilities or costs.

Unwarranted VariationTermUnwarranted Practice Variation, Unexplained Variation

Differences in utilisation or practice unexplained by patient illness, preferences, or evidence-based medicine, unlike warranted variation reflecting legitimate need.

UpcodingTermCode Inflation, Overcoding

A billing practice assigning a higher-level, more complex code than the clinical documentation actually supports, inappropriately increasing reimbursement.

Uptake RateTermAdoption Rate, Rate of Uptake, Technology Incidence, Technology Introduction Rate, New-Tech Entry Rate

The proportion of an eligible population that adopts a new treatment or technology over a given period.

Urgent CareConceptUrgent Treatment, Same-Day Care

Urgent care is same-day treatment for illness or injury that needs prompt attention but is not an emergency, often given outside an emergency department.

Urgent Care CentreTermUrgent Care Clinic, Walk-In Centre

A freestanding facility offering walk-in treatment for prompt but non-emergency conditions, typically operating extended hours beyond a physician's office.

User FeeTermPoint-of-Service Fee, Direct Charge

A direct charge to patients for using a healthcare service, common in some systems as a mechanism to raise revenue and curb overuse.

User-Adjusted CoverageTermUse-Adjusted Coverage, Utilisation-Weighted Coverage

A coverage measure accounting for whether people who received an intervention actually adhered to and properly utilised it as intended.

Usual Customary ReasonableTermUCR, UCR Charge

A methodology insurers use to determine reimbursement for out-of-network care, based on typical charges for similar services in a geographic area.

Utilisation ManagementTermUtilization Management, UM

Techniques payers use to assess and control the appropriateness and volume of healthcare services, including prior authorisation and claims review.

Utilisation Management DesignTermUM Design, Utilisation Management Programme Design

The process of determining a payer's utilisation management programme structure, covering which services require prior authorisation and applicable criteria.

Utilisation RateTermUtilization Rate, Service Use Rate

A measure of how frequently a service or resource is used within a population, typically expressed relative to population size.

Utilisation ReviewConceptUtilization Review, UR

Utilisation review (UR) is a payer's check of whether a patient's care is necessary and appropriate, used to curb unnecessary use and contain costs.

Utilisation TrendTermUtilization Trend, Service Use Trend

The pattern of change in healthcare service use over time, identifying emerging demand shifts or effects of policy changes.