Concept Architecture
Concept
Theoretically, Credible Interval Estimation is the Bayesian procedure used to construct interval estimates from the posterior probability distribution of an unknown parameter. It is founded on Bayesian statistical inference, whereby prior knowledge is formally combined with observed evidence through Bayes' theorem to produce a posterior distribution. In health economics, credible interval estimation is fundamental to Bayesian evidence synthesis, probabilistic sensitivity analysis and decision modelling, where uncertainty surrounding model parameters must be quantified and communicated.
Mathematically, credible interval estimation derives lower and upper interval limits directly from the posterior distribution. The interval is defined so that a specified proportion of posterior probability, typically 95%, lies between the estimated limits. Credible intervals may be constructed as equal-tailed intervals or as highest posterior density (HPD) intervals, depending on the characteristics of the posterior distribution and the estimation method employed.
In practice, credible interval estimation is performed using analytical posterior distributions where available or, more commonly, through Monte Carlo simulation methods such as Markov chain Monte Carlo. Posterior samples are summarised using empirical quantiles or highest posterior density algorithms to estimate interval limits. These intervals are routinely reported in Bayesian health economic models, network meta-analyses and health technology assessments to quantify uncertainty around treatment effects, costs, utilities and incremental cost-effectiveness estimates.
Purpose
Used to estimate posterior uncertainty, construct Bayesian interval estimates, quantify uncertainty in model parameters, support probabilistic decision-making and communicate estimation precision within Bayesian health economic analyses.
Mathematical Formulae
Primary Formula
P(L � ? � U | Data) = 1 ? �
Supporting Formulae
Posterior distribution:
P(? | Data) = (P(Data | ?) ? P(?)) / P(Data)
Equal-tailed interval:
L = Q(� / 2)
U = Q(1 ? � / 2)
where Q denotes the posterior quantile function.
For a 95% credible interval:
L = Q(0.025)
U = Q(0.975)
Related Mathematical Methods
Bayesian Inference
Bayes' Theorem
Posterior Distribution
Highest Posterior Density Interval
Markov Chain Monte Carlo
Bayesian Hierarchical Modelling
Probabilistic Sensitivity Analysis
Example
A Bayesian cost-effectiveness model estimates the incremental net monetary benefit of a new intervention using 20,000 posterior simulations.
Posterior mean = �8,450
Posterior 2.5th percentile = �2,180
Posterior 97.5th percentile = �14,960
The estimated 95% credible interval is therefore:
�2,180 to �14,960
This indicates that, conditional on the observed evidence and prior assumptions, there is a 95% posterior probability that the true incremental net monetary benefit lies within this interval.
Excel Implementation
| Function | Example Formula | Health Economics Application |
|---|---|---|
| PERCENTILE.INC | =PERCENTILE.INC(B2:B20001,0.025) | Estimate lower credible limit from posterior simulations |
| PERCENTILE.INC | =PERCENTILE.INC(B2:B20001,0.975) | Estimate upper credible limit from posterior simulations |
| AVERAGE | =AVERAGE(B2:B20001) | Estimate posterior mean |
| MEDIAN | =MEDIAN(B2:B20001) | Estimate posterior median |
| COUNT | =COUNT(B2:B20001) | Confirm number of posterior simulations |
VBA (Optional)
Automate summarisation of posterior simulation output and estimation of credible intervals for Bayesian health economic models.
Sources
Gelman A, Carlin JB, Stern HS, Dunson DB, Vehtari A, Rubin DB. Bayesian Data Analysis.
Spiegelhalter DJ, Abrams KR, Myles JP. Bayesian Approaches to Clinical Trials and Health-Care Evaluation.
Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation.
NICE. Health Technology Evaluation Manual.
ISPOR-SMDM Modeling Good Research Practices Task Force Reports.
Related Concepts (3)
Library
Publications
1
Statistical Analysis of Cost-Effectiveness Data — Willan & Briggs, 1st Edition ed., 2006 (John Wiley & Sons)
A synthesis of statistical methods for analysing cost-effectiveness data, including net-benefit regression, confidence intervals for the ICER, cost-effectiveness acceptability curves, and covariate adjustment. Part of the Wiley Statistics in Practice series.
BookView source →
Frequently Asked Questions (6)
What is credible interval estimation?
The Bayesian process of calculating a range of plausible values for a parameter based on its estimated posterior probability distribution.
Source: O'Hagan & Stevens 2001
What does credible interval estimation produce from a posterior distribution?
Credible interval estimation is the Bayesian process of deriving a range of plausible values for a parameter from its posterior probability distribution, the distribution that results after combining prior belief with the data. It reads off the interval directly from that posterior, so a ninety-five per cent credible interval is simply the central range holding that much of the posterior probability. This yields the intuitive statement that the parameter probably lies within the range, which requires a prior to be specified alongside the data. Reading a range off the posterior is what it does. Sutton and Abrams (2001) describe this.
Source: Sutton & Abrams 2001
How is credible interval estimation carried out?
Credible interval estimation is carried out by first obtaining the posterior distribution of the parameter, combining the prior with the data through Bayes' theorem, and then finding a range of the posterior that contains the specified probability, such as the central interval between percentiles or the highest posterior density interval. Posterior samples from methods such as Markov chain Monte Carlo are often used. So credible interval estimation is carried out by deriving and summarising the posterior distribution, extracting an interval that holds the desired probability mass, which yields a range whose width reflects the posterior uncertainty about the parameter after the data and prior are combined.
Source: O'Hagan & Stevens 2001
How does credible interval estimation differ from confidence interval estimation?
Credible interval estimation derives a range from the posterior distribution and interprets it as containing the parameter with a stated posterior probability, while confidence interval estimation constructs a range from the sampling distribution and interprets it through long-run coverage over repeated samples. The Bayesian approach uses a prior and makes a direct probability statement about the parameter; the frequentist approach does not. So the two differ in framework and interpretation, with credible interval estimation treating the parameter probabilistically given the data and prior, and confidence interval estimation relying on the frequency properties of the procedure, reflecting the broader distinction between Bayesian and frequentist inference.
Source: O'Hagan & Stevens 2001
What is needed for credible interval estimation?
Credible interval estimation requires a prior distribution for the parameter, the data and a likelihood linking them to the parameter, and computation of the resulting posterior distribution, from which the interval is extracted. When the posterior has no closed form, computational methods such as Markov chain Monte Carlo are used to obtain posterior samples. So credible interval estimation needs a prior, a likelihood, and the means to compute the posterior, which distinguishes it from frequentist estimation by its use of a prior, and the quality of the resulting interval depends on the appropriateness of the prior and the model and on adequate computation of the posterior.
Source: O'Hagan & Stevens 2001
Why use credible interval estimation?
Credible interval estimation is used when a Bayesian approach is adopted, offering a direct probability statement about the parameter that many find more intuitive than the frequentist interpretation, and allowing prior information to be incorporated. It suits complex models and settings where prior knowledge is valuable. So credible interval estimation is used to express uncertainty about a parameter directly as a posterior probability, which is attractive for its interpretability and its ability to combine prior knowledge with data, and it is preferred where a Bayesian framework fits the problem, though it requires specifying a prior and computing the posterior.
Source: O'Hagan & Stevens 2001
Trust Record
Verified by Dr Darrin Baines
British health economist
Professional identity: darrinbaines.org
Verification date: 12 Dec 2025
Content version: 1.0.0
Canonical Identity
- Term code
- HE-ES-SA-040
Stable URI · Machine-readable · Resolvable · CC BY 4.0