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Credible Interval

A range of values, calculated within a Bayesian framework, believed to contain a parameter's true value with a specified posterior probability.

Last reviewedDarrin Baines IP Ltd

Concept Architecture

Concept

Theoretically, a Credible Interval is a Bayesian interval estimate that represents the range within which an unknown parameter lies with a specified posterior probability, conditional on the observed data and the assumed prior distribution. It is founded on Bayesian probability theory, where probability quantifies uncertainty about unknown parameters rather than long-run sampling behaviour. In health economics, credible intervals are widely used to quantify uncertainty surrounding treatment effects, costs, utilities, transition probabilities and other parameters estimated using Bayesian methods.

Mathematically, a credible interval is derived directly from the posterior probability distribution of a parameter. Unlike a frequentist confidence interval, which is based on repeated sampling properties, a credible interval is defined by the posterior distribution and contains a specified proportion of posterior probability mass, commonly 95%. Equal-tailed and highest posterior density (HPD) intervals are the most frequently reported forms.

In practice, credible intervals are calculated after estimating the posterior distribution using analytical Bayesian methods or simulation techniques such as Markov chain Monte Carlo (MCMC). They are routinely reported in Bayesian clinical trials, probabilistic sensitivity analyses, evidence synthesis and health economic decision models to express uncertainty surrounding model parameters and decision outcomes.


Purpose

Used to quantify posterior uncertainty surrounding unknown parameters, summarise Bayesian estimation results, support probabilistic decision-making and communicate uncertainty in health economic models and evidence synthesis.


Mathematical Formulae

Primary Formula

P(L � ? � U | Data) = 1 ? �

where:

? = unknown parameter

L = lower credible limit

U = upper credible limit

Supporting Formulae

Posterior Distribution:

P(? | Data) = (P(Data | ?) ? P(?)) / P(Data)

Equal-tailed credible interval:

P(? < L | Data) = � / 2

P(? > U | Data) = � / 2

For a 95% credible interval:

P(L � ? � U | Data) = 0.95

Related Mathematical Methods

Bayesian Inference

Posterior Distribution

Bayes' Theorem

Highest Posterior Density Interval

Markov Chain Monte Carlo

Probabilistic Sensitivity Analysis

Bayesian Hierarchical Models


Example

A Bayesian network meta-analysis estimates the incremental quality-adjusted life year gain of a new intervention.

Posterior mean = 0.42 QALYs

95% credible interval = (0.18, 0.67)

This indicates that, given the observed evidence and prior assumptions, there is a 95% posterior probability that the true incremental QALY gain lies between 0.18 and 0.67.


Excel Implementation

FunctionExample FormulaHealth Economics Application
PERCENTILE.INC=PERCENTILE.INC(B2:B10001,0.025)Estimate lower equal-tailed credible limit from posterior simulations
PERCENTILE.INC=PERCENTILE.INC(B2:B10001,0.975)Estimate upper equal-tailed credible limit from posterior simulations
AVERAGE=AVERAGE(B2:B10001)Calculate posterior mean
MEDIAN=MEDIAN(B2:B10001)Calculate posterior median
PERCENTILE.INC=PERCENTILE.INC(B2:B10001,0.5)Estimate posterior percentile summaries

VBA (Optional)

Automate extraction of posterior simulation summaries and calculation of credible intervals for Bayesian health economic models.


Sources

Gelman A, Carlin JB, Stern HS, Dunson DB, Vehtari A, Rubin DB. Bayesian Data Analysis.

Spiegelhalter DJ, Abrams KR, Myles JP. Bayesian Approaches to Clinical Trials and Health-Care Evaluation.

Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation.

NICE. Health Technology Evaluation Manual.

ISPOR-SMDM Modeling Good Research Practices Task Force Reports.

Library

Publications

1
  • Book

    Bayesian Methods in Health Economics — Gianluca Baio, 1st Edition ed., 2012 (Chapman & Hall / CRC Press)

    An overview of Bayesian statistical methods for the analysis of health economic data, covering economic evaluation concepts, statistical cost-effectiveness analysis, Bayesian computation and MCMC, and applied health economic evaluation.

Frequently Asked Questions (6)

  • What is a credible interval?

    A range of values, calculated within a Bayesian framework, believed to contain a parameter's true value with a specified posterior probability.

    Source: O'Hagan & Stevens 2001

  • What does a credible interval say about where a parameter lies?

    A credible interval, calculated within a Bayesian framework, is a range that is said to contain a parameter's true value with a stated posterior probability, such as ninety-five per cent. It permits the natural interpretation that the parameter has that probability of lying within the range, given the data and the prior, which is exactly what people often wrongly assume a confidence interval means. It emerges from the posterior distribution, so the prior influences it alongside the data. Stating a probable range for the parameter itself is what it offers. Sutton and Abrams (2001) describe this.

    Source: Sutton & Abrams 2001

  • How is a credible interval interpreted?

    A credible interval is interpreted directly as a probability statement about the parameter: a ninety-five per cent credible interval means that, given the data and the prior, there is a ninety-five per cent posterior probability that the parameter lies within the interval. This differs from a confidence interval, whose probability refers to the procedure over repeated samples. So a credible interval is interpreted as containing the parameter with the stated posterior probability, which is the intuitive interpretation many mistakenly apply to confidence intervals, and this directness is a feature of the Bayesian approach, in which parameters have probability distributions and statements about them are made directly.

    Source: O'Hagan & Stevens 2001

  • How is a credible interval calculated?

    A credible interval is calculated from the posterior distribution of the parameter, by finding a range that contains the specified posterior probability, commonly either the central interval between the relevant percentiles of the posterior or the highest posterior density interval, which is the shortest range containing that probability. So a credible interval is calculated by summarising the posterior distribution, taking a range that holds the desired probability mass, which requires the posterior, obtained by combining the prior with the data through Bayes' theorem, and is often computed from posterior samples generated by methods such as Markov chain Monte Carlo when the posterior has no simple closed form.

    Source: O'Hagan & Stevens 2001

  • How does a credible interval differ from a confidence interval?

    A credible interval, from Bayesian analysis, is interpreted as containing the parameter with a stated posterior probability given the data and prior, while a confidence interval, from frequentist analysis, is interpreted through its long-run coverage, the proportion of such intervals over repeated samples that would contain the fixed parameter. The credible interval makes a direct probability statement about the parameter; the confidence interval does not. So the two differ in interpretation and framework, with the credible interval treating the parameter probabilistically and the confidence interval treating it as fixed, and although they can coincide numerically in some cases, their meanings are distinct.

    Source: O'Hagan & Stevens 2001

  • What is the role of the prior in a credible interval?

    The prior influences a credible interval because the interval is derived from the posterior distribution, which combines the prior with the data; when the data are strong, the prior has little effect, but when the data are limited, the prior can substantially affect the interval. So the prior plays a role in determining a credible interval, especially with sparse data, which is why the choice of prior matters and its influence is often examined, since an informative prior can narrow or shift the interval, and reporting how the prior affects the credible interval supports transparent Bayesian inference where the interval reflects both the data and the prior beliefs.

    Source: O'Hagan & Stevens 2001

Trust Record

Verified by Dr Darrin Baines

British health economist

Professional identity: darrinbaines.org

Verification date: 12 Dec 2025

Content version: 1.0.0

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Term code
HE-ES-SA-039

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