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Principal Component

In principal component analysis, a derived variable combining original observed variables to capture the maximum possible variance, uncorrelated with prior components.

Last reviewedDarrin Baines IP Ltd

Concept Architecture

Concept


Theoretically, Principal Component is a derived variable obtained through Principal Component Analysis (PCA) that represents a linear combination of the original variables. Each principal component captures the maximum possible variance remaining in the dataset while being orthogonal to all preceding components. Principal components provide a lower-dimensional representation of multivariate data without substantial loss of information and are widely used in statistical modelling, exploratory data analysis, and machine learning.

Mathematically, a principal component is defined as an eigenvector of the covariance or correlation matrix of the observed variables. The corresponding eigenvalue quantifies the amount of variance explained by that component. Successive principal components are constrained to be mutually orthogonal and are ordered according to decreasing explained variance. Component scores are calculated by projecting observations onto the eigenvectors.

In practice, principal components are estimated by eigenvalue decomposition or singular value decomposition of the covariance or correlation matrix. In health economics they are used to reduce highly correlated variables, construct composite indices, summarise patient-reported outcome measures, identify latent dimensions of healthcare utilisation, and improve computational efficiency in predictive modelling.

Purpose


Used to transform correlated variables into orthogonal components that explain the maximum variance, supporting dimensionality reduction, exploratory analysis, composite measure development, and statistical modelling in health economics.


Mathematical Formulae

Primary Formula

PC? = a??x? + a??x? + ? + a??x?

where:

  • PC? = kth principal component
  • a?? = loading of variable i on component k
  • x? = observed variable

Supporting Formulae

Cov(X)a = ?a

Variance explained:

Var(PC?) = ??

Proportion of variance explained:

PV? = ?? � ???

Component score:

z = Xa

where:

  • ? = eigenvalue
  • a = eigenvector
  • X = standardised data matrix

Related Mathematical Methods

  • Principal Component Analysis
  • Eigenvalue Decomposition
  • Singular Value Decomposition
  • Covariance Matrix
  • Correlation Matrix
  • Factor Analysis
  • Dimension Reduction
  • Multivariate Analysis

Example

A health economist analyses five correlated indicators of healthcare utilisation:

  • General practitioner visits
  • Outpatient appointments
  • Hospital admissions
  • Prescription counts
  • Emergency department attendances

After standardisation, PCA identifies:

Eigenvalue (PC?) = 3.45

Total variance = 5.00

Variance explained:

PV? = 3.45 � 5.00

= 69%

The first principal component represents an overall healthcare utilisation index explaining 69% of the total variation across the five utilisation measures.


Excel Implementation

FunctionExample FormulaHealth Economics Application
MMULT=MMULT(StandardisedData,LoadingMatrix)Calculate principal component scores from standardised variables.
TRANSPOSE=TRANSPOSE(LoadingRange)Manipulate eigenvector loading matrices.
SUMPRODUCT=SUMPRODUCT(ObservationRange,LoadingRange)Calculate an individual principal component score.
STANDARDIZE=STANDARDIZE(A2,AVERAGE(A:A),STDEV.S(A:A))Standardise variables before PCA.
LINEST=LINEST(YRange,XRange,TRUE,TRUE)Support exploratory analyses following dimensionality reduction.

VBA (Optional)

Automate calculation of principal component scores, explained variance, and loading matrices for multivariate health economic datasets.


Sources

  • Hotelling H. Analysis of a Complex of Statistical Variables into Principal Components. Journal of Educational Psychology. 1933.
  • Jolliffe IT. Principal Component Analysis. 2nd ed.
  • Jolliffe IT, Cadima J. Principal Component Analysis: A Review and Recent Developments. Philosophical Transactions of the Royal Society A. 2016.
  • Johnson RA, Wichern DW. Applied Multivariate Statistical Analysis.
  • Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation.
  • Drummond MF, et al. Methods for the Economic Evaluation of Health Care Programmes.

Library

Publications

1
  • Book

    Statistical Analysis of Cost-Effectiveness Data — Willan & Briggs, 1st Edition ed., 2006 (John Wiley & Sons)

    A synthesis of statistical methods for analysing cost-effectiveness data, including net-benefit regression, confidence intervals for the ICER, cost-effectiveness acceptability curves, and covariate adjustment. Part of the Wiley Statistics in Practice series.

Frequently Asked Questions (6)

  • What is a principal component?

    In principal component analysis, a derived variable combining original observed variables to capture the maximum possible variance, uncorrelated with prior components.

    Source: Pearson 1901

  • What does a principal component capture from the original variables?

    A principal component is a new variable formed by combining the original measured variables so as to capture as much of their total variation as possible. The first component captures the most, the next captures the most of what remains while staying uncorrelated with the first, and so on, so a few components can summarise many variables. This makes principal component analysis a way to reduce dimensionality, condensing correlated measurements into a handful of informative summaries. Packing maximum variance into a new variable is what it does. Kline (2015) describes this.

    Source: Kline 2015

  • How are principal components derived?

    Principal components are derived from the covariance or correlation matrix of the variables by finding the directions, given by the eigenvectors, along which the data vary most, with the associated eigenvalues giving the variance captured. The first component is the direction of greatest variance, and each subsequent component the greatest remaining variance while orthogonal to the previous ones. So principal components are derived as the eigenvectors of the variables' covariance or correlation matrix, ordered by the variance they explain, which produces uncorrelated components that successively capture the maximum remaining variance, providing a mathematically optimal summary of the data's variation.

    Source: Pearson 1901

  • What is principal component analysis used for?

    Principal component analysis is used for data reduction, summarising many correlated variables by a few components that capture most of the variance; for visualisation, by plotting the leading components; and for addressing collinearity, since the components are uncorrelated. So principal component analysis is used to simplify high-dimensional data, retaining most of the information in fewer dimensions, which is valuable for exploration, visualisation, and as a preprocessing step for other analyses, and because the components are uncorrelated it can also handle collinearity among predictors, making principal components a widely used tool for reducing and understanding multivariate data.

    Source: Pearson 1901

  • How does a principal component differ from a factor?

    A principal component is a combination of the observed variables constructed to capture maximum variance, being a summary of the data, while a factor in factor analysis is a latent variable hypothesised to cause the correlations among the observed variables, representing an underlying construct. Principal component analysis is descriptive data reduction; factor analysis models latent structure. So a principal component and a factor differ in interpretation and purpose, with the component a variance-maximising combination of the variables and the factor a hypothesised underlying cause, which is why principal component analysis is used for summarising and reducing data and factor analysis for identifying latent constructs, though the two are related and sometimes confused.

    Source: Pearson 1901

  • How is the number of principal components chosen?

    The number of principal components to retain is chosen to capture a sufficient proportion of the total variance while reducing dimensionality, using criteria such as the cumulative variance explained, the eigenvalues, or a scree plot showing where the explained variance levels off. So the number of principal components is selected by balancing how much variance is retained against the reduction in dimensions, keeping enough components to summarise the data adequately without retaining many that add little, which is why the pattern of eigenvalues and the cumulative variance are examined, along with the purpose of the analysis, to decide how many components meaningfully represent the data.

    Source: Pearson 1901

Trust Record

Verified by Dr Darrin Baines

British health economist

Professional identity: darrinbaines.org

Verification date: 23 Dec 2025

Content version: 1.0.0

Canonical Identity

Term code
HE-ES-SA-166

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