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Discrete Model

A model in which time advances in fixed, distinct steps, such as one-year cycles, rather than flowing continuously.

Last reviewedDarrin Baines IP Ltd

Concept Architecture

Concept

Theoretically, a Discrete Model is a mathematical model in which time, events, state changes or system transitions occur at distinct intervals or discrete points rather than continuously. The model represents healthcare processes as a sequence of separate events or cycles, making it suitable for clinical pathways and disease processes that can be naturally described by discrete transitions. In health economics, discrete models are widely used to evaluate healthcare interventions through decision trees, Markov models, discrete-event simulation and other state-transition frameworks.

Mathematically, discrete models describe changes using recurrence relations, transition matrices or discrete probability distributions. The state of the system is updated only at predefined decision points or events rather than continuously through time. Costs, utilities and health outcomes are accumulated at each discrete interval and combined over the model time horizon to estimate overall economic outcomes.

In practice, discrete models are parameterised using clinical trials, observational studies, registries and epidemiological data. Cycle lengths are selected to reflect the clinical process being modelled, and transition probabilities are estimated for each interval. Discrete models are implemented in health technology assessment, chronic disease modelling, screening evaluations and resource allocation analyses where clinical events occur at identifiable decision points or time intervals.


Purpose

Used to represent healthcare processes as sequences of discrete events or time cycles, estimate long-term clinical and economic outcomes, and evaluate the cost-effectiveness of alternative healthcare interventions.


Mathematical Formulae

Primary Formula

Discrete state-transition equation:

????? = ?????

where:

  • ??? = state distribution at cycle t
  • ?? = transition probability matrix
  • ????? = state distribution at cycle t + 1

Supporting Formulae

General recurrence relation:

x??? = f(x?)

Discounted cumulative outcome:

Y = ????? Y? / (1 + r)?

where:

  • Y? = outcome during cycle t
  • r = discount rate

Related Mathematical Methods

  • State-transition modelling
  • Markov cohort modelling
  • Decision tree analysis
  • Discrete-event simulation
  • Matrix algebra
  • Monte Carlo simulation

Example

A Markov cohort model follows 5,000 patients using annual cycles.

Initial state distribution:

??? = [1, 0, 0]

Transition matrix:

?? =

Library

Publications

1
  • Journal article

    Conceptualizing a Model: A Report of the ISPOR-SMDM Modeling Good Research Practices Task Force-2 — Roberts, Russell, Paltiel, Chambers, McEwan & Krahn, Task Force Report 2 ed., 2012 (Value in Health / Medical Decision Making)

    Best-practice guidance on model conceptualisation — defining the decision problem, scoping, and choosing an appropriate model structure before implementation.

Frequently Asked Questions (6)

  • What is a discrete model?

    A model in which time advances in fixed, distinct steps, such as one-year cycles, rather than flowing continuously.

    Source: Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation. Oxford University Press; 2006. doi:10.1093/oso/9780198526629.001.0001.

  • Why do many health economic models advance time in discrete steps?

    Advancing time in fixed steps, such as monthly or yearly cycles, suits health processes that are naturally reviewed at intervals and matches the way much clinical data are recorded. It also keeps the calculations tractable, since the model needs to update states only once per cycle rather than continuously. The step must be short enough that little of importance happens within a single cycle unnoticed, which is why the choice of cycle length is a modelling decision in its own right. Briggs and colleagues (2006) explain this design.

    Source: Briggs et al. 2006

  • How does a discrete model represent time?

    A discrete model represents time as a sequence of fixed steps, or cycles, updating the state at each. During a cycle, transitions between states occur according to per-cycle probabilities, and costs and effects are accrued, then the state is updated for the next cycle. Events within a cycle are treated as happening at defined points, such as the start, end, or middle. The choice of cycle length affects the model, since a shorter cycle represents timing more finely but requires more computation.

    Source: Briggs, Claxton & Sculpher 2006

  • How does a discrete model differ from a continuous model?

    A discrete model advances time in fixed steps and updates the state at each, whereas a continuous model treats time as flowing smoothly, with change occurring at every instant, usually through differential equations. Discrete models are simpler to build and implement and suit processes represented adequately by cycles, while continuous models capture the timing of events more finely but are harder to formulate and solve. The choice depends on whether the fine timing of events matters for the results.

    Source: Briggs, Claxton & Sculpher 2006

  • What is the role of cycle length in a discrete model?

    Cycle length determines how finely a discrete model represents the timing of events: a shorter cycle captures rapid changes and reduces the error from treating events as occurring only at cycle points, but requires more computation, while a longer cycle is simpler but may misrepresent processes that change quickly within it. The cycle should be short enough that events and transitions are well approximated. A correction, such as the half-cycle correction, is often applied to reduce the error from discrete timing.

    Source: Briggs, Claxton & Sculpher 2006

  • What are the advantages of a discrete model?

    A discrete model is simple to build, implement, and understand, since it advances in clear steps and updates the state at each, making its logic transparent and its computation straightforward. It suits processes that can be represented adequately by cycles, and it avoids the mathematical demands of continuous models. This simplicity, together with the wide use of Markov cohort models, makes discrete-time representation a standard and convenient choice in health economic modelling, provided the cycle length captures the timing adequately.

    Source: Briggs, Claxton & Sculpher 2006

Trust Record

Verified by Dr Darrin Baines

British health economist

Professional identity: darrinbaines.org

Verification date: 29 Sep 2025

Content version: 1.0.0

Canonical Identity

Term code
HE-EM-DM-022

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