Concept Architecture
Concept
Theoretically, DFBETAS is a regression diagnostic statistic that measures the influence of an individual observation on each estimated regression coefficient. It is founded on influence analysis within ordinary least squares regression and quantifies the standardised change in a regression coefficient when a single observation is omitted from model estimation. In health economics, DFBETAS is used to identify influential observations affecting estimates of treatment effects, healthcare costs, health utilities and other regression model parameters.
Mathematically, DFBETAS is calculated as the difference between a regression coefficient estimated using the full dataset and the corresponding coefficient estimated after deleting one observation, divided by the estimated standard error of the deleted-observation coefficient. Standardisation allows influence to be compared across regression coefficients with different scales and units. Large absolute values indicate observations exerting substantial influence on individual parameter estimates.
In practice, DFBETAS is computed after fitting a regression model and is interpreted alongside Cook's Distance, leverage and studentised residuals. Influential observations identified by DFBETAS are investigated to determine whether they represent data errors, atypical but valid observations or clinically important subgroups. The statistic supports model diagnostics but should not be used in isolation to justify excluding observations.
Purpose
Used to identify observations that disproportionately influence individual regression coefficients, assess model stability, support regression diagnostics and improve interpretation of regression analyses in health economics.
Mathematical Formulae
Primary Formula
DFBETAS?? = (??? ? ???(?i)) / SE(???(?i))
where:
??? = regression coefficient estimated using all observations
???(?i) = regression coefficient after deleting observation i
SE(???(?i)) = standard error of the deleted-observation estimate
Supporting Formulae
A commonly used guideline is:
|DFBETAS| > 2 / �n
where n is the sample size.
Related Mathematical Methods
Cook's Distance
Leverage
Studentised Residuals
Ordinary Least Squares
Influence Diagnostics
Hat Matrix
Regression Diagnostics
Example
A health economist develops a multiple regression model to estimate annual healthcare costs using age, disease severity and treatment status.
One observation produces:
?? (treatment) = ?�520
?? (treatment, observation removed) = ?�455
SE = �42
DFBETAS = (?520 ? (?455)) / 42
DFBETAS = ?1.55
The observation has a noticeable influence on the treatment coefficient and is investigated further alongside other diagnostic measures before any modelling decisions are made.
Excel Implementation
| Function | Example Formula | Health Economics Application |
|---|---|---|
| LINEST | =LINEST(B2:B201,C2:E201,TRUE,TRUE) | Estimate regression coefficients |
| INDEX | =INDEX(LINEST(B2:B201,C2:E201,TRUE,TRUE),1,1) | Extract regression coefficient |
| SQRT | =SQRT(COUNT(B2:B201)) | Calculate threshold denominator |
| Formula | =2/SQRT(COUNT(B2:B201)) | Calculate common DFBETAS screening threshold |
| ABS | =ABS(B2) | Evaluate absolute DFBETAS values against the threshold |
VBA (Optional)
Automate deletion diagnostics by recalculating regression coefficients after sequential removal of observations and producing DFBETAS influence reports.
Sources
Belsley DA, Kuh E, Welsch RE. Regression Diagnostics: Identifying Influential Data and Sources of Collinearity.
Cook RD, Weisberg S. Residuals and Influence in Regression.
Kutner MH, Nachtsheim CJ, Neter J, Li W. Applied Linear Statistical Models.
Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation.
Drummond MF, Sculpher MJ, Claxton K, Stoddart GL, Torrance GW. Methods for the Economic Evaluation of Health Care Programmes.
Related Concepts (2)
Library
Publications
1
Statistical Analysis of Cost-Effectiveness Data — Willan & Briggs, 1st Edition ed., 2006 (John Wiley & Sons)
A synthesis of statistical methods for analysing cost-effectiveness data, including net-benefit regression, confidence intervals for the ICER, cost-effectiveness acceptability curves, and covariate adjustment. Part of the Wiley Statistics in Practice series.
BookView source →
Frequently Asked Questions (6)
What are DFBETAS?
A standardised version of the DFBETA diagnostic, scaled by its standard error, allowing influence of observations to be compared consistently across models.
Source: Belsley, Kuh & Welsch 1980
What does DFBETAS reveal about a single observation's influence?
DFBETAS reveals how much an individual observation influences each estimated regression coefficient, measuring the change in a coefficient when that one point is removed, scaled by its standard error. Because it is standardised, its values can be compared across coefficients and models, and it pinpoints influence on specific predictors rather than on the fit as a whole. A large value flags a case that noticeably shifts a particular coefficient, prompting scrutiny. Isolating a point's effect on each coefficient is what it does. Kirkwood and Sterne (2003) describe this diagnostic.
Source: Kirkwood & Sterne 2003
How are DFBETAS calculated?
DFBETAS are calculated for each observation and each coefficient as the difference between the coefficient estimated with all the data and the coefficient estimated with that observation removed, divided by an estimate of the coefficient's standard error. This gives a standardised measure of the change attributable to the observation. So DFBETAS are calculated by refitting the model without each observation, taking the change in each coefficient, and standardising it by its standard error, which yields, for every observation and coefficient, a scaled value indicating how strongly that observation influences that particular coefficient, comparable across coefficients because of the standardisation.
Source: Belsley, Kuh & Welsch 1980
How are DFBETAS interpreted?
DFBETAS are interpreted by their magnitude, with larger absolute values indicating greater influence of an observation on a coefficient; a common rough threshold flags values exceeding two divided by the square root of the sample size, though such cut-offs are guides rather than strict rules. So DFBETAS are interpreted by identifying observations whose standardised influence on a coefficient is large relative to a threshold or to the other observations, marking them as influential for that particular coefficient, which prompts investigation of those cases, since a large DFBETAS value signals that a single observation substantially affects the estimate of a specific regression parameter.
Source: Belsley, Kuh & Welsch 1980
How do DFBETAS differ from Cook's distance?
DFBETAS measure the influence of an observation on each individual coefficient separately, giving a value for every observation and coefficient, while Cook's distance summarises an observation's overall influence on all the fitted values, or the whole set of coefficients, in a single measure. So DFBETAS and Cook's distance differ in granularity, with DFBETAS pinpointing which coefficients an observation affects and Cook's distance giving an aggregate measure of its total influence, and they are complementary, since Cook's distance flags generally influential observations and DFBETAS reveal which specific coefficients those or other observations most affect.
Source: Cook 1977
Why are DFBETAS useful?
DFBETAS are useful because they reveal not just whether an observation is influential but which specific coefficients it affects, allowing targeted investigation of how individual data points drive particular estimates. This is valuable when the interest is in specific coefficients. So DFBETAS are useful for diagnosing the influence of observations at the level of individual coefficients, complementing overall influence measures, which helps the analyst understand how particular cases affect the estimates of interest and decide whether the results depend unduly on a few observations, supporting robust and transparent regression modelling.
Source: Belsley, Kuh & Welsch 1980
Trust Record
Verified by Dr Darrin Baines
British health economist
Professional identity: darrinbaines.org
Verification date: 15 Dec 2025
Content version: 1.0.0
Canonical Identity
- Persistent URI
- https://healtheconomics.wiki/concept/dfbetas
- Term code
- HE-ES-SA-049
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