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Bootstrapping Method

The specific procedure of repeatedly resampling, with replacement, from a dataset to empirically approximate the sampling distribution of a statistic of interest.

Last reviewedDarrin Baines IP Ltd

Concept Architecture

Concept


Theoretically, Bootstrapping Method is a statistical resampling technique that estimates the sampling distribution of a statistic by repeatedly drawing samples with replacement from the original dataset. It represents the practical implementation of bootstrap theory and provides a flexible framework for statistical inference without relying on strong distributional assumptions. The method exists to estimate uncertainty, bias and sampling variability for statistics whose theoretical distributions are unknown or difficult to derive.

Mathematically, the Bootstrapping Method generates a large number of bootstrap samples, each equal in size to the original dataset and obtained by random sampling with replacement. The statistic of interest is recalculated for every resample, producing an empirical sampling distribution from which standard errors, confidence intervals and bias estimates are derived.

In practice, the Bootstrapping Method is implemented using hundreds or thousands of resamples within statistical software and simulation models. It is widely applied in regression analysis, survival modelling, health economic evaluation and cost-effectiveness analysis to quantify parameter uncertainty, validate statistical models and support probabilistic decision-making.


Purpose


Used to estimate empirical sampling distributions, quantify statistical uncertainty, calculate standard errors and confidence intervals and support robust statistical and health economic analyses when analytical methods are unavailable or impractical.


Mathematical Formulae

Primary Formula

??? = Statistic(X?*)

where:

  • ??? = estimate from bootstrap sample i
  • X?* = bootstrap sample drawn with replacement from the original dataset

Supporting Formulae

?? = (1 / B) ? ??????? ???

SE? = �[(1 / (B ? 1)) ? ??????? (??? ? ??)�]

Bias = ?? ? ??

where:

  • B = number of bootstrap replications
  • ?? = estimate from the original dataset

Related Mathematical Methods

  • Bootstrapping
  • Bootstrap Standard Error
  • Bootstrap Confidence Interval
  • Bias-Corrected and Accelerated Bootstrap
  • Non-Parametric Bootstrap
  • Monte Carlo Simulation
  • Jackknife

Example


A health economic study estimates the mean annual treatment cost using patient-level data.

The Bootstrapping Method generates 10,000 resamples with replacement from the original dataset.

The mean cost is recalculated for every bootstrap sample, producing an empirical sampling distribution from which the standard error and 95% confidence interval are estimated.


Excel Implementation

FunctionExample FormulaHealth Economics Application
RANDARRAY=RANDARRAY(1000,1)Generates random values for bootstrap resampling.
INDEX=INDEX(B$2:B$101,RANDBETWEEN(1,100))Draws observations with replacement from the original dataset.
AVERAGE=AVERAGE(C2:C101)Calculates the statistic for each bootstrap sample.
STDEV.S=STDEV.S(D2:D10001)Estimates the Bootstrap Standard Error across bootstrap replications.

VBA (Optional)


A VBA macro can automate bootstrap resampling, generate thousands of bootstrap datasets, estimate model parameters and produce empirical confidence intervals and uncertainty summaries.


Sources

  • Efron B. Bootstrap methods: another look at the jackknife. Annals of Statistics. 1979;7(1):1?26.
  • Efron B, Tibshirani RJ. An Introduction to the Bootstrap.
  • Davison AC, Hinkley DV. Bootstrap Methods and Their Application.
  • Carpenter J, Bithell J. Bootstrap confidence intervals: when, which, what? Statistics in Medicine. 2000;19:1141?1164.
  • Briggs A, Claxton K, Sculpher M. Decision Modelling for Health Economic Evaluation.

Library

Publications

1
  • Book

    Bayesian Methods in Health Economics — Gianluca Baio, 1st Edition ed., 2012 (Chapman & Hall / CRC Press)

    An overview of Bayesian statistical methods for the analysis of health economic data, covering economic evaluation concepts, statistical cost-effectiveness analysis, Bayesian computation and MCMC, and applied health economic evaluation.

Frequently Asked Questions (6)

  • What is the bootstrapping method?

    The specific procedure of repeatedly resampling, with replacement, from a dataset to empirically approximate the sampling distribution of a statistic of interest.

    Source: Efron 1979

  • What does the bootstrapping method do with the observed dataset?

    The bootstrapping method repeatedly draws new samples from an observed dataset, each formed by sampling with replacement to the original size, and computes the statistic of interest on every one. Doing this thousands of times builds an empirical picture of how the statistic varies from sample to sample, which stands in for its true sampling distribution. From that spread it derives standard errors and confidence intervals without any formula, treating the data themselves as the population. Learning variability by resampling the data is what it does. Efron and Tibshirani (1993) describe this procedure.

    Source: Efron & Tibshirani 1993

  • What are the steps of the bootstrapping method?

    The steps of the bootstrapping method are to draw a resample of the same size as the original data by sampling with replacement; to compute the statistic of interest on that resample; to repeat this many times, producing many values of the statistic; and to summarise the resulting distribution, for example by its standard deviation for a standard error or its percentiles for a confidence interval. So the bootstrapping method proceeds by repeated resampling, recomputation, and summarisation, building an empirical sampling distribution from the data, which is then used to quantify the uncertainty of the statistic without relying on analytical formulas or distributional assumptions.

    Source: Efron 1979

  • How does the bootstrapping method estimate uncertainty?

    The bootstrapping method estimates uncertainty by using the spread of a statistic across many resamples as an approximation of its sampling variability: the standard deviation of the statistic over the resamples gives a standard error, and the percentiles of the resampled values give a confidence interval. So the bootstrapping method estimates uncertainty empirically from the variability of the statistic under resampling, treating the observed data as representative of the population, which allows standard errors and confidence intervals to be obtained for statistics whose theoretical sampling distributions are unknown or hard to derive, making it a flexible tool for inference.

    Source: Efron 1979

  • How does the bootstrapping method differ from traditional inference?

    The bootstrapping method estimates a statistic's sampling distribution empirically by resampling the data, while traditional inference derives it analytically from assumed distributions and formulas, such as assuming normality to compute a standard error. Bootstrapping relies on computation and few assumptions, whereas traditional methods rely on mathematical derivation and distributional assumptions. So the bootstrapping method differs from traditional inference in obtaining uncertainty from resampling rather than from theory, which makes it applicable where analytical results are unavailable or their assumptions doubtful, though it is more computationally intensive and still depends on the sample being representative of the population.

    Source: Efron 1979

  • When is the bootstrapping method appropriate?

    The bootstrapping method is appropriate when a statistic's sampling distribution cannot be derived easily or when the assumptions of formula-based inference are questionable, and when the sample is large enough and representative enough for resampling to reflect the population's variability. So the bootstrapping method is appropriate for quantifying uncertainty in complex or non-standard statistics and where distributional assumptions are doubtful, provided the sample is adequate, since its validity rests on the data representing the population, which means it is applied with attention to sample size and representativeness and is less reliable for very small samples or certain extreme statistics.

    Source: Efron 1979

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Verified by Dr Darrin Baines

British health economist

Professional identity: darrinbaines.org

Verification date: 11 Dec 2025

Content version: 1.0.0

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Term code
HE-ES-SA-018

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